Louis Guibout Selected Research

norbixin

1/2022	Structural analysis of unstable norbixin isomers guided by pure shift nuclear magnetic resonance.
1/2021	A2E-induced inflammation and angiogenesis in RPE cells in vitro are modulated by PPAR-α, -β/δ, -γ, and RXR antagonists and by norbixin.
1/2020	Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease.
1/2016	Norbixin Protects Retinal Pigmented Epithelium Cells and Photoreceptors against A2E-Mediated Phototoxicity In Vitro and In Vivo.

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Louis Guibout Research Topics

Disease

4	Macular Degeneration (Age-Related Maculopathy) 01/2022 - 01/2016
2	Vision Disorders (Hemeralopia) 01/2020 - 01/2016
1	Inflammation (Inflammations) 01/2021
1	Stargardt Disease 01/2020
1	Phototoxic Dermatitis (Phototoxicity) 01/2016

Drug/Important Bio-Agent (IBA)

4	norbixinIBA 01/2022 - 01/2016
3	A2-E (N-retinylidene-N-retinylethanolamine)IBA 01/2021 - 01/2016
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2021
1	diazepinylbenzoic acidIBA 01/2021
1	LipofuscinIBA 01/2020
1	Retinal Pigments (Pigments, Visual)IBA 01/2016
1	Retinaldehyde (Retinal)IBA 01/2016